LncRNA PVT1 regulates atrial fibrosis via miR-128-3p-SP1-TGF-β1-Smad axis in atrial fibrillation

Role of serum TGF-β1 level in atrial fibrosis and outcome after catheter ablation for paroxysmal atrial fibrillation

This study aimed to evaluate the relationship between serum transforming growth factor-β1 (TGF-β1) concentration and atrial fibrosis and to determine whether plasma TGF-β1 concentration is an independent predictor of atrial fibrillation (AF) recurrence after catheter ablation.We included 98 consecutive patients who underwent catheter ablation, including 38 with paroxysmal AF (AF group) and 60 w...

H19 lncRNA regulates keratinocyte differentiation by targeting miR-130b-3p

Aberrant differentiation of keratinocytes has been demonstrated to be associated with a number of skin diseases. A growing number of studies have showed that long noncoding RNAs (lncRNAs) have an important part in gene regulation, however, the role of lncRNAs in keratinocyte differentiation remains to be largely unknown. In the present study, we demonstrated that lncRNA-H19 act as an endogenous...

Fibrosis, myofibroblasts, and atrial fibrillation.

Atrial fibrosis progression in patients with Atrial Fibrillation

Methods Eighty-eight patients (58% male, mean age 60.4+/-14.7) with AF who underwent late gadolinium enhancement MRI (LGE-MRI) to assess the degree of atrial tissue fibrotic changes were included in this study. All patients underwent at least 2 or more LGE-MRI separated by more than 3 months of follow up. Progression of fibrosis was defined as an increase in fibrosis area by more than 5% (Figur...

LncRNA NEAT1 enhances the radio-resistance of cervical cancer via miR-193b-3p/CCND1 axis

LncRNAs have become a hot topic in various cancer-related researches. Radio-resistance is a great threat for cancer therapy. However, how lncRNAs affect the radio-resistance in cervical cancer is masked. As for our paper, it was discovered that NEAT1 was highly expressed in cervical cancer tissues and non-sensitive tissues as well as radio-resistant cell lines. And the overexpression of NEAT1 a...